Keno France 3 Diffusion Rating: 3,4/5 9727 votes

Description

  • Organisation/Company: European Synchrotron Radiation Facility

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    Dynamic macrostructural and microstructural changes take place from the mid-fetal stage to 2 years after birth. Delineating structural changes of the brain during early development provides new insights into the complicated processes of both typical development and the pathological mechanisms underl.

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  • Research Field: Chemistry Engineering › Chemical engineering Pharmacological sciences Physics
  • Researcher Profile: First Stage Researcher (R1)
  • Application Deadline: 02/03/2021 22:00 - Europe/Athens
    • France
  • Location: France › Grenoble
  • Type Of Contract: Temporary
  • Job Status: Full-time
  • Hours Per Week: 35
  • Reference Number: XN21ILL

    • The European Synchrotron, the ESRF, is an international research centre basedin Grenoble, France.

    Through its innovative engineering, pioneering scientific vision and a strongcommitment from its 700 staff members, the ESRF is recognised as one of thetop research facilities worldwide. Its particle accelerator produces intenseX-ray beams that are used by thousands of scientists each year for experimentsin diverse fields such as biology, medicine, environmental sciences, culturalheritage, materials science, and physics.

    France

    Supported by 22 countries, the ESRF is an equal opportunity employer andencourages diversity.

    The quest for novel drug delivery vehicles is increasing in importance,especially considering personalized medicine and emerging drug modalities.Long-lasting drug delivery with tailored release kinetics is stillchallenging. In this project we aim to generate fundamental knowledge for thetailoring of such platforms based on supramolecular gels.

    Supramolecular gels are based on small organic molecule gelatorsmacroscopically immobilizing the solvent at concentrations well below 1 wt%.However, solvent and drug molecules diffuse on the microscopic level withvariable impact of the gel fibre network. Using spectroscopy accessing thediffusion dynamics of solvent and drug molecules on different timescales andconnecting this with macroscopic drug release kinetics and gel rheology willenable us to tailor diffusion and drug release kinetics from these gels.

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    You will join the spectroscopy group at the ILL as PhD student of theUniversity of Manchester and primarily employ neutron spectroscopy in thisproject. This is complemented by techniques such as small angle scattering toprobe the gel structure, and nuclear magnetic resonance spectroscopy forlonger diffusion timescales.

    The project runs in collaboration with our industrial project partnerAstraZeneca, UK, and you will be placed with the partner for 3 months for drugrelease studies.

    Further information may be obtained from Katharina Edkins (tel.: +44 (0)161275 8348, email: katharina.edkins@manchester.ac.uk) and from Tilo Seydel(+33 (0)4 76 20 75 79, email: seydel@ill.eu).

    Additional comments

    The successful candidate will be enrolled at the doctoral academy of theUniversity of Manchester as part of the Division of Pharmacy and based full-time at the ILL (Grenoble, France), other than a 3-month secondment atAstra-Zeneca in Macclesfield, UK. 3 months of the degree will be held at theUniversity of Manchester for training purposes. Furthermore, a variedpedagogical training programme will be offered to the successful candidatethroughout the 3-year PhD project.

    More details on the InnovaXN programme onwww. innovaxn.eu

    Offer RequirementsSkills/Qualifications
  • Degree allowing enrolment for a PhD (such as 2:1 or higher in an undergraduate degree, MSc, Master 2 de Recherche, Laurea or equivalent) in physics, physical chemistry, pharmacy, chemistry, chemical engineering or closely related science
    • Keno France 3 Diffusion
  • A background in X-ray or neutron scattering, and/or experience working with and characterizing (supramolecular) gels will be an advantage.
  • A strong interest in both experimental work performing sample preparations and scattering experiments, as well as in data analysis and modeling involving the use of python or MATLAB will be required. Moreover, excellent communication skills and autonomous work in a multi-faceted team at 3 different locations will be needed.

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  • Proficiency in English (a proof of upper-intermediate level would be advantageous and can be provided in the application. Applicants originating from native-English-speaking countries can apply without the need for proof of level. An official degree conducted in English will be also accepted as a proof; Students without proof of upper-intermediate level may still apply and their level of English will be checked during the interview).
  • Compliance with the Marie Sklodowska-Curie mobility rule: candidates may not have resided or carried out their main activity (work, studies, etc.) in France for more than twelve months in the three years immediately before the date of recruitment.
  • At the date of recruitment, early-stage researchers must be in the first four years of their research careers and have not yet been awarded a doctoral degree.
  • Candidates must satisfy eligibility criteria according to the partner university requirements for PhD enrolment.

    • More details about the application procedure onwww. innovaxn.eu/for-students/documents/

    Contact Information
  • Organisation/Company: European Synchrotron Radiation Facility
  • Organisation Type: International / Intergovernmental Organisation
  • Website: https:// www. esrf.eu/

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    France

    Keno France 3 Diffusion Tensor

  • Country: France
  • City: Grenoble
  • Postal Code: 38000
  • Street: 71, avenue des Martyrs
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